Endocrine Abstracts

Hyperprolactinemia is known to have a wide differential with multiple causes including physiological, pathological and pharmacological. Drug induced causes of hyperprolactinemia are myriad however these become significant when prolactin levels rise to proportions that lead to clinical manifestations. We present a case of a 40 years old lady who was referred to endocrinology for an irregular menstrual cycle. Initial investigations revealed a prolactin level of 5767 mIU/l (range...

Traditional literature has dictated diabetes to be a chronic irreversible disease with progression of micro and macrovascular complications. Modern medicine has now started to include bariatric surgery, starch restriction as potential interventions which could control diabetes at initial stages. Our case report is unique as it illustrates patient directed reversal of diabetes with lifestyle intervention. 77 years old gentleman was diagnosed with Type 2 diabetes at the age of 5...

Background: Immune checkpoint inhibitors are now commonly used in melanoma, renal cell carcinoma and non-small cell lung cancers. Patients on immune check point inhibitors experience at least one type of immune related adverse event(irAEs) which can occur even after discontinuation of therapy. Endocrine toxicities are commonly reported irAE′s and tend to be irreversible. The most frequently recognized endocrine complications include thyroid dysfunction (30%) hypophysitis...

A 50 year-old lady was referred to the endocrine service for evaluation of significantly elevated 3-methoxytyramine (3-MT) levels. Past medical history included well controlled HIV and hypertension controlled by a single agent only (amlodipine). On one occasion, she was noted to have an elevated systolic blood pressure of 189 mmHg in clinic and therefore 24 h urinary metanephrines were requested. She did not have any other symptoms to suggest excess catecholamines. Systems rev...

Objective: Hyperprolactinaemia is one of the most common disorders of the hypothalamic-pituitary axis. Endocrine Society guidelines state that a single prolactin measurement in a blood sample obtained at any time of day is adequate to confirm hyperprolactinaemia. However, prolactin levels can be confounded by physiological stimuli, e.g sleep, stress or exercise. Our objective was to assess the clinical significance of prolactin level obta...

A 43 year old Somali woman presented with increasing fatigue, difficulty getting out of her chair and 15 kg weight gain over a one month. Past medical history included paranoid psychosis, nasal congestion due to adenotonsillarhypertrophy, and human immunodeficiency virus (HIV). Her HIV infection was well controlled (viral load <50RNA copies/ml), with excellent immunological reconstitution (CD4 count >500 cells/mm3). Current medicat...

A 22-year-old female first presented in 2008 with a six-month history of galactorrhoea and irregular menses. She had hyperprolactinaemia (2401 mIU/L), a negative macroprolactin screen and her pituitary MRI scan demonstrated a 4 mm microadenoma. Her cannulated prolactin levels were >1500 mIU/L. TFTs, IGF-1, cortisol and remaining pituitary profile were within normal range.Cabergoline was commenced and gradually i...

: We report a case of a 56-year-old gentleman who presented to the endocrine clinic with erectile dysfunction. He had elevated SHBG levels, MCV, gamma GT, ferritin, iron and markedly elevated testosterone and transferrin saturation (GGT 167 IU/l, ferritin 1128 ug/l, testosterone 62.5 nmol/l). He had a marginally low platelet count (123X109/l). He denied ever taking testosterone supplements. His calculated free testosterone was normal. His full blood count was otherwise unremar...

Objective: Hyperprolactinaemia is one of the most common disorders of the hypothalamic-pituitary axis. Endocrine Society guidelines state that a single prolactin measurement in a blood sample obtained at any time of day is adequate to confirm hyperprolactinaemia. However, prolactin levels can be confounded by physiological stimuli, e.g sleep, stress or exercise. Our objective was to assess the clinical significance of prolactin level obta...

A 43 year old Somali woman presented with increasing fatigue, difficulty getting out of her chair and 15 kg weight gain over a one month. Past medical history included paranoid psychosis, nasal congestion due to adenotonsillarhypertrophy, and human immunodeficiency virus (HIV). Her HIV infection was well controlled (viral load <50RNA copies/ml), with excellent immunological reconstitution (CD4 count >500 cells/mm3). Current medicat...